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SNPs in ultraconserved elements and familial breast Cancer Risk

Yang, R, Frank, B, Hemminki, K, Bartram, C R, Wappenschmidt, B, Sutter, C, Kiechle, M, Bugert, P, Schmutzler, R K, Arnold, N, Weber, Bernhard H. F. , Niederacher, D, Meindl, A and Burwinkel, B (2008) SNPs in ultraconserved elements and familial breast Cancer Risk. Carcinogenesis 29 (2), pp. 351-355.

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Ultraconserved elements (UCEs) are segments of >200 bp length showing absolute sequence identity between orthologous regions of human, rat and mouse genomes. The selection factors acting on these UCEs are still unknown. Recent studies have shown that UCEs function as long-range enhancers of flanking genes or are involved in splicing when overlapping with exons. The depletion of UCEs among copy ...


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Item type:Article
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
18174240PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35922
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