Genetic variants within miR-126 and miR-335 are not associated with breast cancer risk

Yang, R, Dick, M, Marme, F, Schneeweiss, A, Langheinz, A, Hemminki, K, Sutter, C, Bugert, P, Wappenschmidt, B, Varon, R, Schott, S, Weber, Bernhard H. F. , Niederacher, D, Arnold, N, Meindl, A, Bartram, C R, Schmutzler, R K, Müller, H, Arndt, V, Brenner, H, Sohn, C und Burwinkel, B (2011) Genetic variants within miR-126 and miR-335 are not associated with breast cancer risk. Breast Cancer Research and Treatment 127 (2), S. 549-554.

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Zusammenfassung

MicroRNAs (miRNAs) are 20–22 nt non-coding RNAs which promote the degradation of target mRNAs or repression of the translation of mRNAs by sequence specific targeting. Many miRNAs are considered as oncogenes or tumor suppressors. MiR-126 and miR-335 play roles in the suppression of breast cancer metastasis by inhibiting tumor growth, proliferation, and cell invasion. The effects of SNPs within ...

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