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Genetic variants within miR-126 and miR-335 are not associated with breast cancer risk

Yang, R. ; Dick, M. ; Marme, F. ; Schneeweiss, A. ; Langheinz, A. ; Hemminki, K. ; Sutter, C. ; Bugert, P. ; Wappenschmidt, B. ; Varon, R. ; Schott, S. ; Weber, Bernhard H. F. ; Niederacher, D. ; Arnold, N. ; Meindl, A. ; Bartram, C. R. ; Schmutzler, R. K. ; Müller, H. ; Arndt, V. ; Brenner, H. ; Sohn, C. ; Burwinkel, B.


MicroRNAs (miRNAs) are 20–22 nt non-coding RNAs which promote the degradation of target mRNAs or repression of the translation of mRNAs by sequence specific targeting. Many miRNAs are considered as oncogenes or tumor suppressors. MiR-126 and miR-335 play roles in the suppression of breast cancer metastasis by inhibiting tumor growth, proliferation, and cell invasion. The effects of SNPs within ...


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