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Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype

Sofat, R, Casas, J P, Webster, A R, Bird, A C, Mann, S S, Yates, J R, Moore, A T, Sepp, T, Cipriani, V, Bunce, C, Khan, J C, Shahid, H, Swaroop, A, Abecasis, G, Branham, K E, Zareparsi, S, Bergen, A A, Klaver, C C, Baas, D C, Zhang, K, Chen, Y, Gibbs, D, Weber, Bernhard H. F. and et al, . (2012) Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype. International Journal of Epidemiology 41 (1), pp. 250-262.

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Abstract

Background: ariation in the complement factor H gene (CFH) is associated with risk of late age-related macular degeneration (AMD). Previous studies have been case–control studies in populations of European ancestry with little differentiation in AMD subtype, and insufficient power to confirm or refute effect modification by smoking. Methods: To precisely quantify the association of the single ...

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Item type:Article
Date:2012
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1093/ije/dyr204DOI
22253316PubMed ID
Keywords:Age-related macular degeneration (AMD), Complement factor H gene, meta-ananlysis
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:36029
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