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Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype

Sofat, R. ; Casas, J. P. ; Webster, A. R. ; Bird, A. C. ; Mann, S. S. ; Yates, J. R. ; Moore, A. T. ; Sepp, T. ; Cipriani, V. ; Bunce, C. ; Khan, J. C. ; Shahid, H. ; Swaroop, A. ; Abecasis, G. ; Branham, K. E. ; Zareparsi, S. ; Bergen, A. A. ; Klaver, C. C. ; Baas, D. C. ; Zhang, K. ; Chen, Y. ; Gibbs, D. ; Weber, Bernhard H. F. ; et al, .


Background: ariation in the complement factor H gene (CFH) is associated with risk of late age-related macular degeneration (AMD). Previous studies have been case–control studies in populations of European ancestry with little differentiation in AMD subtype, and insufficient power to confirm or refute effect modification by smoking. Methods: To precisely quantify the association of the single ...


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