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Nucleolus association of chromosomal domains is largely maintained in cellular senescence despite massive nuclear reorganisation

Dillinger, Stefan, Straub, Tobias and Nemeth, Attila (2017) Nucleolus association of chromosomal domains is largely maintained in cellular senescence despite massive nuclear reorganisation. PLoS ONE 12 (6), e0178821.

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Date of publication of this fulltext: 04 Sep 2017 09:34

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Other URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178821

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Mammalian chromosomes are organized in structural and functional domains of 0.1-10 Mb, which are characterized by high self-association frequencies in the nuclear space and different contact probabilities with nuclear sub-compartments. They exhibit distinct chromatin modification patterns, gene expression levels and replication timing. Recently, nucleolus-associated chromosomal domains (NADs) ...

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Item type:Article
Date:2 June 2017
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > House of the Ribosome
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0178821DOI
Keywords:LAMINA INTERACTIONS; HETEROCHROMATIN FORMATION; ORGANIZER REGIONS; GENE-EXPRESSION; HUMAN GENOME; CHROMATIN ORGANIZATION; SAHF FORMATION; INACTIVE-X; CELLS; ARCHITECTURE;
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36056
Owner only: item control page

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