Nucleolus association of chromosomal domains is largely maintained in cellular senescence despite massive nuclear reorganisation

URN to cite this document:: urn:nbn:de:bvb:355-epub-360562
DOI to cite this document:: 10.5283/epub.36056

Dillinger, Stefan ; Straub, Tobias

; Németh, Attila

Preview

PDF
(6MB)

Date of publication of this fulltext: 04 Sep 2017 09:34

Alternative links to fulltext:DOI Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

Mammalian chromosomes are organized in structural and functional domains of 0.1-10 Mb, which are characterized by high self-association frequencies in the nuclear space and different contact probabilities with nuclear sub-compartments. They exhibit distinct chromatin modification patterns, gene expression levels and replication timing. Recently, nucleolus-associated chromosomal domains (NADs) ...