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In Search of NPY Y4R Antagonists: Incorporation of Carbamoylated Arginine, Aza-Amino Acids, or d-Amino Acids into Oligopeptides Derived from the C-Termini of the Endogenous Agonists

URN to cite this document:
urn:nbn:de:bvb:355-epub-361124
DOI to cite this document:
10.5283/epub.36112
Kuhn, Kilian K. ; Littmann, Timo ; Dukorn, Stefanie ; Tanaka, Miho ; Keller, Max ; Ozawa, Takeaki ; Bernhardt, Günther ; Buschauer, Armin
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Date of publication of this fulltext: 29 Aug 2017 09:34


Abstract

The cross-linked pentapeptides (2R, 7R)-diaminooctanedioyl- bis(Tyr-Arg-Leu-Arg-Tyr-amide) ((2R, 7R)BVD- 74D, (2R, 7R)-1) and octanedioyl-bis(Tyr-Arg-Leu-ArgTyr- amide) (2) as well as the pentapeptide Ac-Tyr-Arg-LeuArg- Tyr-amide (3) were previously described as neuropeptide Y Y-4 receptor (Y4R) partial agonists. Here, we report on a series of analogues of (2R, 7R)-1 and 2 in which Arg(2), ...

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