In Search of NPY Y4R Antagonists: Incorporation of Carbamoylated Arginine, Aza-Amino Acids, or d-Amino Acids into Oligopeptides Derived from the C-Termini of the Endogenous Agonists

URN zum Zitieren dieses Dokuments: urn:nbn:de:bvb:355-epub-361124

Kuhn, Kilian K., Littmann, Timo, Dukorn, Stefanie, Tanaka, Miho, Keller, Max , Ozawa, Takeaki, Bernhardt, Günther und Buschauer, Armin (2017) In Search of NPY Y4R Antagonists: Incorporation of Carbamoylated Arginine, Aza-Amino Acids, or d-Amino Acids into Oligopeptides Derived from the C-Termini of the Endogenous Agonists. ACS Omega 2 (7), S. 3616-3631.

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Andere URL zum Volltext: http://doi.org/10.1021/acsomega.7b00451

Zusammenfassung

The cross-linked pentapeptides (2R,7R)-diaminooctanedioyl-bis(Tyr-Arg-Leu-Arg-Tyr-amide) ((2R,7R)-BVD-74D, (2R,7R)-1) and octanedioyl-bis(Tyr-Arg-Leu-Arg-Tyr-amide) (2) as well as the pentapeptide Ac-Tyr-Arg-Leu-Arg-Tyr-amide (3) were previously described as neuropeptide Y Y4 receptor (Y4R) partial agonists. Here, we report on a series of analogues of (2R,7R)-1 and 2 in which Arg2, Leu3, or Arg4 ...

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