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In Search of NPY Y4R Antagonists: Incorporation of Carbamoylated Arginine, Aza-Amino Acids, or d-Amino Acids into Oligopeptides Derived from the C-Termini of the Endogenous Agonists

Kuhn, Kilian K., Littmann, Timo, Dukorn, Stefanie, Tanaka, Miho, Keller, Max, Ozawa, Takeaki, Bernhardt, Günther and Buschauer, Armin (2017) In Search of NPY Y4R Antagonists: Incorporation of Carbamoylated Arginine, Aza-Amino Acids, or d-Amino Acids into Oligopeptides Derived from the C-Termini of the Endogenous Agonists. ACS Omega 2 (7), pp. 3616-3631.

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Date of publication of this fulltext: 29 Aug 2017 09:34

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Other URL: http://doi.org/10.1021/acsomega.7b00451

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

The cross-linked pentapeptides (2R, 7R)-diaminooctanedioyl- bis(Tyr-Arg-Leu-Arg-Tyr-amide) ((2R, 7R)BVD- 74D, (2R, 7R)-1) and octanedioyl-bis(Tyr-Arg-Leu-ArgTyr- amide) (2) as well as the pentapeptide Ac-Tyr-Arg-LeuArg- Tyr-amide (3) were previously described as neuropeptide Y Y-4 receptor (Y4R) partial agonists. Here, we report on a series of analogues of (2R, 7R)-1 and 2 in which Arg(2), ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
10.1021/acsomega.7b00451DOI
Keywords:Y-1 RECEPTOR ANTAGONISTS; NEUROPEPTIDE-Y; HIGH-AFFINITY; PANCREATIC-POLYPEPTIDE; PEPTIDE; LIGANDS; ANALOGS; IDENTIFICATION; LUMINESCENCE; INHIBITOR;
Dewey Decimal Classification:600 Technology > 615 Pharmacy
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36112
Owner only: item control page

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