Kuhn, Kilian K., Littmann, Timo, Dukorn, Stefanie, Tanaka, Miho, Keller, Max, Ozawa, Takeaki, Bernhardt, Günther and Buschauer, Armin 
(2017)
In Search of NPY Y4R Antagonists: Incorporation of Carbamoylated Arginine, Aza-Amino Acids, or d-Amino Acids into Oligopeptides Derived from the C-Termini of the Endogenous Agonists.
ACS Omega 2 (7), pp. 3616-3631.
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Other URL: http://doi.org/10.1021/acsomega.7b00451
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Abstract
The cross-linked pentapeptides (2R, 7R)-diaminooctanedioyl- bis(Tyr-Arg-Leu-Arg-Tyr-amide) ((2R, 7R)BVD- 74D, (2R, 7R)-1) and octanedioyl-bis(Tyr-Arg-Leu-ArgTyr- amide) (2) as well as the pentapeptide Ac-Tyr-Arg-LeuArg- Tyr-amide (3) were previously described as neuropeptide Y Y-4 receptor (Y4R) partial agonists. Here, we report on a series of analogues of (2R, 7R)-1 and 2 in which Arg(2), ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 2017 | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) | ||||
| Identification Number: |
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| Keywords: | Y-1 RECEPTOR ANTAGONISTS; NEUROPEPTIDE-Y; HIGH-AFFINITY; PANCREATIC-POLYPEPTIDE; PEPTIDE; LIGANDS; ANALOGS; IDENTIFICATION; LUMINESCENCE; INHIBITOR; | ||||
| Dewey Decimal Classification: | 600 Technology > 615 Pharmacy 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 36112 |
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