Keratinocytic epidermal nevi are associated with mosaic RAS mutations

URN to cite this document:: urn:nbn:de:bvb:355-epub-361423
DOI to cite this document:: 10.5283/epub.36142

Hafner, Christian ; Toll, Agustí ; Gantner, Susanne ; Mauerer, Andreas ; Dietmaier, Wolfgang ; Landthaler, Michael

Preview

License: Allianz- bzw. Nationallizenz
PDF - Published Version
(219kB)

Date of publication of this fulltext: 04 Sep 2017 10:10

Alternative links to fulltext:DOI

Details

Preview

Export bibliographical data

Abstract

Background: Activating RAS mutations in the germline cause rare developmental disorders such as Costello syndrome. Somatic RAS mutations are found in approximately 30% of human cancers. Keratinocytic epidermal nevi (KEN) represent benign congenital skin lesions arranged along Blaschko's lines. A subgroup of KEN is caused by hotspot oncogenic FGFR3 and PIK3CA mutations in mosaicism, but the ...