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Keratinocytic epidermal nevi are associated with mosaic RAS mutations

Hafner, Christian, Toll, Agustí, Gantner, Susanne, Mauerer, Andreas, Dietmaier, Wolfgang and Landthaler, Michael (2012) Keratinocytic epidermal nevi are associated with mosaic RAS mutations. Journal of Medical Genetics 49, pp. 249-283.

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Abstract

Background: Activating RAS mutations in the germline cause rare developmental disorders such as Costello syndrome. Somatic RAS mutations are found in approximately 30% of human cancers. Keratinocytic epidermal nevi (KEN) represent benign congenital skin lesions arranged along Blaschko's lines. A subgroup of KEN is caused by hotspot oncogenic FGFR3 and PIK3CA mutations in mosaicism, but the ...

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Item type:Article
Date:2012
Institutions:Medicine > Lehrstuhl für Dermatologie und Venerologie
Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
10.1136/jmedgenet-2011-100637DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:36142
Owner only: item control page

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