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Keratinocytic epidermal nevi are associated with mosaic RAS mutations

URN to cite this document:
urn:nbn:de:bvb:355-epub-361423
DOI to cite this document:
10.5283/epub.36142
Hafner, Christian ; Toll, Agustí ; Gantner, Susanne ; Mauerer, Andreas ; Dietmaier, Wolfgang ; Landthaler, Michael
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Date of publication of this fulltext: 04 Sep 2017 10:10


Abstract

Background: Activating RAS mutations in the germline cause rare developmental disorders such as Costello syndrome. Somatic RAS mutations are found in approximately 30% of human cancers. Keratinocytic epidermal nevi (KEN) represent benign congenital skin lesions arranged along Blaschko's lines. A subgroup of KEN is caused by hotspot oncogenic FGFR3 and PIK3CA mutations in mosaicism, but the ...

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