IL-7 receptor α expressing B cells act proinflammatory in collagen-induced arthritis and are inhibited by sympathetic neurotransmitters

URN to cite this document:: urn:nbn:de:bvb:355-epub-361618
DOI to cite this document:: 10.5283/epub.36161

Pongratz, Georg ; Anthofer, Judith M. ; Melzer, Madlen ; Anders, Sven ; Grässel, Susanne ; Straub, Rainer H.

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Date of publication of this fulltext: 07 Sep 2017 06:30

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Abstract

Objectives: The sympathetic nervous system (SNS) as well as the interleukin (IL)-7/IL-7 receptor (IL-7R) system play a role in the pathogenesis of arthritis. However, the target cells and mechanisms involved are not fully resolved. The goal of this study was to determine if B cells are influenced by IL-7 and to investigate the possible interplay between the SNS and the IL-7/IL-7R system on B ...