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Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn's disease

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Gutiérrez, A. ; Scharl, M. ; Sempere, L. ; Holler, Ernst ; Zapater, P. ; Almenta, I. ; González-Navajas, J. M. ; Such, J. ; Wiest, Reiner
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 07 Sep 2017 09:30


Objective: The aetiology of Crohn's disease (CD) has been related to nucleotide-binding oligomerisation domain containing 2 (NOD2) and ATG16L1 gene variants. The observation of bacterial DNA translocation in patients with CD led us to hypothesise that this process may be facilitated in patients with NOD2/ATG16L1-variant genotypes, affecting the efficacy of anti-tumour necrosis factor (TNF) ...


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