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Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn's disease

Gutiérrez, A., Scharl, M., Sempere, L., Holler, Ernst, Zapater, P., Almenta, I., González-Navajas, J. M., Such, J. and Wiest, Reiner (2014) Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn's disease. Gut 63, pp. 272-280.

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Abstract

Objective: The aetiology of Crohn's disease (CD) has been related to nucleotide-binding oligomerisation domain containing 2 (NOD2) and ATG16L1 gene variants. The observation of bacterial DNA translocation in patients with CD led us to hypothesise that this process may be facilitated in patients with NOD2/ATG16L1-variant genotypes, affecting the efficacy of anti-tumour necrosis factor (TNF) ...

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Item type:Article
Date:2014
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
10.1136/gutjnl-2012-303557DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:36162
Owner only: item control page

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