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Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn's disease

URN to cite this document:
urn:nbn:de:bvb:355-epub-361625
DOI to cite this document:
10.5283/epub.36162
Gutiérrez, A. ; Scharl, M. ; Sempere, L. ; Holler, Ernst ; Zapater, P. ; Almenta, I. ; González-Navajas, J. M. ; Such, J. ; Wiest, Reiner
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Date of publication of this fulltext: 07 Sep 2017 09:30



Abstract

Objective: The aetiology of Crohn's disease (CD) has been related to nucleotide-binding oligomerisation domain containing 2 (NOD2) and ATG16L1 gene variants. The observation of bacterial DNA translocation in patients with CD led us to hypothesise that this process may be facilitated in patients with NOD2/ATG16L1-variant genotypes, affecting the efficacy of anti-tumour necrosis factor (TNF) ...

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