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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-361639
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.36163
Zusammenfassung
Background: Uveal melanoma (UM) is the most common primary cancer of the eye in adults. About half of the patients are at risk of developing metastatic disease resulting in a poor clinical prognosis. Metastatic progression is strongly associated with loss of one chromosome 3 in the tumour (monosomy 3). The tumour suppressor gene BAP1 was found to be recurrently mutated in UM with monosomy 3. ...
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