| License: Allianz- bzw. Nationallizenz PDF - Published Version (808kB) |
- URN to cite this document:
- urn:nbn:de:bvb:355-epub-361639
- DOI to cite this document:
- 10.5283/epub.36163
Alternative links to fulltext:DOI
Abstract
Background Uveal melanoma (UM) is the most common primary cancer of the eye in adults. About half of the patients are at risk of developing metastatic disease resulting in a poor clinical prognosis. Metastatic progression is strongly associated with loss of one chromosome 3 in the tumour (monosomy 3). The tumour suppressor gene BAP1 was found to be recurrently mutated in UM with monosomy 3. ...

Owner only: item control page