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BAP1 germline mutation in two first grade family members with uveal melanoma

Maerker, David A., Zeschnigk, M., Nelles, J., Lohmann, D. R., Worm, K., Bosserhoff, Anja-Katrin, Krupar, Rosemarie and Jägle, Herbert (2014) BAP1 germline mutation in two first grade family members with uveal melanoma. British Journal of Ophthalmology 98, pp. 224-227.

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Abstract

Background: Uveal melanoma (UM) is the most common primary cancer of the eye in adults. About half of the patients are at risk of developing metastatic disease resulting in a poor clinical prognosis. Metastatic progression is strongly associated with loss of one chromosome 3 in the tumour (monosomy 3). The tumour suppressor gene BAP1 was found to be recurrently mutated in UM with monosomy 3. ...

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Item type:Article
Date:2014
Institutions:Medicine > Lehrstuhl für Augenheilkunde
Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
10.1136/bjophthalmol-2013-303814DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:36163
Owner only: item control page

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