Molecular targets for antifibrotic therapy in liver disease: using magic bullets for crossfire rather than a one-sided shotgun attack

URN to cite this document:: urn:nbn:de:bvb:355-epub-361645
DOI to cite this document:: 10.5283/epub.36164

Hellerbrand, Claus ; ;

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Date of publication of this fulltext: 07 Sep 2017 10:06

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Abstract

Objective The aetiology of Crohn's disease (CD) has been related to nucleotide-binding oligomerisation domain containing 2 (NOD2) and ATG16L1 gene variants. The observation of bacterial DNA translocation in patients with CD led us to hypothesise that this process may be facilitated in patients with NOD2/ATG16L1-variant genotypes, affecting the efficacy of anti-tumour necrosis factor (TNF) ...