Anti-inflammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis

URN to cite this document:: urn:nbn:de:bvb:355-epub-361722
DOI to cite this document:: 10.5283/epub.36172

Jenei-Lanzl, Zsuzsa ; Capellino, Silvia ; Kees, Frieder

; Fleck, Martin ; Lowin, Torsten ; Straub, Rainer H.

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Date of publication of this fulltext: 08 Sep 2017 11:57

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Abstract

Objectives: Studies in rheumatoid arthritis (RA), osteoarthritis (OA) and mice with arthritis demonstrated tyrosine hydroxylase-positive (TH+) cells in arthritic synovium and parallel loss of sympathetic nerve fibres. The exact function of TH+ cells and mode of TH induction are not known. Methods: Synovial cells of RA/OA were isolated and cultured under normoxic/hypoxic conditions with/without ...