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Anti-inflammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis

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Jenei-Lanzl, Zsuzsa ; Capellino, Silvia ; Kees, Frieder ; Fleck, Martin ; Lowin, Torsten ; Straub, Rainer H.
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 08 Sep 2017 11:57


Objectives: Studies in rheumatoid arthritis (RA), osteoarthritis (OA) and mice with arthritis demonstrated tyrosine hydroxylase-positive (TH+) cells in arthritic synovium and parallel loss of sympathetic nerve fibres. The exact function of TH+ cells and mode of TH induction are not known. Methods: Synovial cells of RA/OA were isolated and cultured under normoxic/hypoxic conditions with/without ...


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