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Pals1 functions as a tumor suppressor regulating cell polarity, Hippo signaling and cancer progression

Panichkina, Olga (2018) Pals1 functions as a tumor suppressor regulating cell polarity, Hippo signaling and cancer progression. PhD, Universität Regensburg.

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Date of publication of this fulltext: 16 Oct 2018 07:11

Abstract (English)

Epithelial cell polarity is of vital importance for the organization and function of epithelial tissues and is primarily maintained by three protein complexes, the Crumbs complex, the Par complex and the Scribble complex. Most of the polarity proteins within these complexes are highly conserved and play pivotal roles in embryonic development, cell-cell adhesion and cell migration. Recent studies ...

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Translation of the abstract (German)

Die Polarität der Epithelzellen ist von entscheidender Bedeutung für die Organisation und Funktion von Epithelgeweben. Es wird hauptsächlich von drei Proteinkomplexen - dem Crumbs-Komplex, dem Par-Komplex und dem Scribble-Komplex, aufgebaut. Die meisten Polaritätsproteine innerhalb dieser Komplexe sind hoch konserviert und spielen eine zentrale Rolle in der embryonalen Entwicklung, ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:16 October 2018
Referee:Prof. Dr. Dr. Michael Krahn
Date of exam:10 October 2017
Institutions:UNSPECIFIED
Keywords:Pals1, cell polarity, Hippo pathway, epithelial mesenchymal transition
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36237
Owner only: item control page

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