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Neutrophil microvesicles resolve gout by inhibiting C5a-mediated priming of the inflammasome

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Cumpelik, A. ; Ankli, B. ; Zecher, Daniel
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 03 Nov 2017 10:49


Objectives Gout is a highly inflammatory but self-limiting joint disease induced by the precipitation of monosodium urate (MSU) crystals. While it is well established that inflammasome activation by MSU mediates acute inflammation, little is known about the mechanism controlling its spontaneous resolution. The aim of this study was to analyse the role of neutrophil-derived microvesicles ...


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