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The association between acute graft-versus-host disease and antimicrobial peptide expression in the gastrointestinal tract after allogeneic stem cell transplantation

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Weber, Daniela ; Frauenschläger, Katrin ; Ghimire, Sakhila ; Peter, Katrin ; Panzer, Isabella ; Hiergeist, Andreas ; Weber, Markus ; Kutny, Daniel ; Wolff, Daniel ; Grube, Matthias ; Huber, Elisabeth ; Oefner, Peter ; Gessner, Andre ; Hehlgans, Thomas ; Herr, Wolfgang ; Holler, Ernst
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Jan 2018 11:37


Intestinal microbiota disruption is associated with acute gastrointestinal (GI) Graft-versus-Host Disease (GvHD) and poor outcome after allogeneic stem cell transplantation (ASCT). Here, in a retrospective analysis of 200 patients undergoing ASCT at the Regensburg University Medical Center, we assessed the relative expression of Paneth cell antimicrobial peptides (AMPs), Human Defensins (HD) 5 ...


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