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Click Hydrogels for Controlled Local Antibody Delivery

Gregoritza, Manuel (2018) Click Hydrogels for Controlled Local Antibody Delivery. PhD, Universität Regensburg.

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Date of publication of this fulltext: 30 Nov 2018 06:23

Abstract (English)

This thesis was focused on the development of click hydrogels for the controlled local delivery of therapeutic antibodies. In 2001, the term “click chemistry” was first introduced by Sharpless and coworkers as an umbrella term for “spring-loaded” reactions that are modular, wide in scope, stereospecific, give high yields, proceed at simple conditions, and do not form toxic by-products. Since ...

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Translation of the abstract (German)

Diese Dissertation beschäftigte sich mit der Entwicklung von Klick Hydrogelen für die kontrollierte lokale Freisetzung therapeutischer Antikörper. Im Jahr 2001 wurde der Begriff "Klick-Chemie" von Sharpless und seinen Mitarbeitern als Oberbegriff für "federgespannte" Reaktionen eingeführt, die modular, vielseitig einsetzbar und stereospezifisch sind, hohe Ausbeuten liefern und unter sehr ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:30 November 2018
Referee:Prof. Dr. Achim Göpferich
Date of exam:17 November 2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Keywords:click chemistry, hydrogel, antibody, controlled release, Diels-Alder reaction, thiol-ene reaction, age-related macular degeneration, microfluidics, polyanion
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36364
Owner only: item control page

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