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Chromatin remodelers, their implication in cancer and therapeutic potential

URN to cite this document:
urn:nbn:de:bvb:355-epub-364057
Manelyte, Laura
Date of publication of this fulltext: 04 Dec 2017 15:38


Abstract

The chromatin remodeling complexes alter chromatin structures. They remodel nucleosomes in ATP-dependent manner and have essential roles in DNA damage repair, recombination, replication and transcriptional control. Increasing evidences indicate that subunits of chromatin remodelers are mutated and/or deregulated in a number of human cancers, and how they influence the cancer gene expression ...

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