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Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study

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Greimel, Felix ; Scheuerer, Christine ; Gessner, Andre ; Simon, Michaela ; Kalteis, Thomas ; Grifka, Joachim ; Benditz, Achim ; Springorum, Hans-Robert ; Schaumburger, Jens
Date of publication of this fulltext: 04 Dec 2017 14:15


The efficacy of antibiotic monotherapy and combination therapy in the treatment of implant-associated infection by Staphylococcus aureus was evaluated in an animal study. The femoral medullary cavity of 66 male Wistar rats was contaminated with S. aureus (ATCC 29213) and a metal device was implanted, of which 61 could be evaluated. Six treatment groups were studied: flucloxacillin, flucloxacillin ...


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