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Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study

Greimel, Felix, Scheuerer, Christine, Gessner, Andre, Simon, Michaela, Kalteis, Thomas, Grifka, Joachim, Benditz, Achim, Springorum, Hans-Robert and Schaumburger, Jens (2017) Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study. Drug Design, Development and Therapy 11, pp. 1729-1736.

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Date of publication of this fulltext: 04 Dec 2017 14:15

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Other URL: http://doi.org/10.2147/DDDT.S138888, https://www.dovepress.com/efficacy-of-antibiotic-treatment-of-implant-associated-staphylococcus--peer-reviewed-fulltext-article-DDDT

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

The efficacy of antibiotic monotherapy and combination therapy in the treatment of implant-associated infection by Staphylococcus aureus was evaluated in an animal study. The femoral medullary cavity of 66 male Wistar rats was contaminated with S. aureus (ATCC 29213) and a metal device was implanted, of which 61 could be evaluated. Six treatment groups were studied: flucloxacillin, flucloxacillin ...

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Item type:Article
Date:14 June 2017
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Medicine > Lehrstuhl für Orthopädie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.2147/DDDT.S138888DOI
Keywords:FOREIGN-BODY INFECTION; GRAM-POSITIVE BONE; JOINT INFECTIONS; MOUSE MODEL; METHICILLIN; RESISTANT; PHARMACOKINETICS; FLUOROQUINOLONES; PHARMACODYNAMICS; ARTHROPLASTIES; moxifloxacin; rifampin; flucloxacillin; implant-associated infection; prosthetic infection; Staphylococcus aureus
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36406
Owner only: item control page

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