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A Photo-Crosslinkable Biotin Derivative of the Phosphoantigen (E )-4-Hydroxy-3-Methylbut-2-Enyl Diphosphate (HMBPP) Activates Vγ9Vδ2 T Cells and Binds to the HMBPP Site of BTN3A1

Mattarei, Andrea, Enzinger, Monika, Gu, Siyi , Karunakaran, Mohindar Murugesh, Kimmel, Brigitte, Berner, Nicole, Adams, Erin J., Herrmann, Thomas and Amslinger, Sabine (2017) A Photo-Crosslinkable Biotin Derivative of the Phosphoantigen (E )-4-Hydroxy-3-Methylbut-2-Enyl Diphosphate (HMBPP) Activates Vγ9Vδ2 T Cells and Binds to the HMBPP Site of BTN3A1. Chemistry - A European Journal 23 (49), pp. 11945-11954.

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Other URL: http://doi.org/10.1002/chem.201702650


Abstract

V gamma 9V delta 2 T cells play an important role in the cross talk of the innate and adaptive immune system. For their activation by phosphoantigens (PAgs), both cell surface receptors, the eponymous V gamma 9V delta 2 T cell antigen receptors (V gamma 9V delta 2 TCRs) on V gamma 9V delta 2 T cells and butyrophilin 3A1 (BTN3A1) on the phosphoantigen-"presenting" cell, are mandatory. To find yet ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ValueType
10.1002/chem.201702650DOI
Keywords:(E)-1-HYDROXY-2-METHYL-BUT-2-ENYL 4-DIPHOSPHATE; PHOSPHORYLATED ANTIGENS; TUMOR-CELLS; PYROPHOSPHATE; STIMULATION; RECOGNITION; PRENYLTRANSFERASES; BIOSYNTHESIS; SYNTHASE; RECEPTOR; B30.2 domain; BTN3A1; HMBPP; phosphoantigen; photoaffinity label
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36437
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