Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation

URN to cite this document:: urn:nbn:de:bvb:355-epub-365363
DOI to cite this document:: 10.5283/epub.36536

Meyre, David

; Winkler, Thomas W. ; Justice, Anne E. ; Cupples, L. Adrienne

; Kronenberg, Florian ; Kutalik, Zoltán ; Heid, Iris M.

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Date of publication of this fulltext: 19 Jan 2018 08:44

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Abstract

Genome-wide association meta-analyses (GWAMAs) conducted separately by two strata have identified differences in genetic effects between strata, such as sex-differences for body fat distribution. However, there are several approaches to identify such differences and an uncertainty which approach to use. Assuming the availability of stratified GWAMA results, we compare various approaches to ...