Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation

• URN zum Zitieren dieses Dokuments: urn:nbn:de:bvb:355-epub-365363

Meyre, David, Winkler, Thomas W., Justice, Anne E., Cupples, L. Adrienne, Kronenberg, Florian, Kutalik, Zoltán und Heid, Iris M. (2017) Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation. PLoS ONE 12 (7), e0181038.

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Andere URL zum Volltext: http://doi.org/10.1371/journal.pone.0181038, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181038

Zusammenfassung

Genome-wide association meta-analyses (GWAMAs) conducted separately by two strata have identified differences in genetic effects between strata, such as sex-differences for body fat distribution. However, there are several approaches to identify such differences and an uncertainty which approach to use. Assuming the availability of stratified GWAMA results, we compare various approaches to ...

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