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Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation

Meyre, David , Winkler, Thomas W., Justice, Anne E., Cupples, L. Adrienne , Kronenberg, Florian, Kutalik, Zoltán and Heid, Iris M. (2017) Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation. PLoS ONE 12 (7), e0181038.

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Date of publication of this fulltext: 19 Jan 2018 08:44

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Other URL: http://doi.org/10.1371/journal.pone.0181038, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181038

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Genome-wide association meta-analyses (GWAMAs) conducted separately by two strata have identified differences in genetic effects between strata, such as sex-differences for body fat distribution. However, there are several approaches to identify such differences and an uncertainty which approach to use. Assuming the availability of stratified GWAMA results, we compare various approaches to ...

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Item type:Article
Date:27 July 2017
Institutions:Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0181038DOI
Keywords:BODY-MASS INDEX; ENVIRONMENT INTERACTION; QUANTITATIVE TRAITS; FAT DISTRIBUTION; ASSOCIATION; LOCI; SUSCEPTIBILITY; EPIDEMIOLOGY; EFFICIENT; VARIANTS;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36536
Owner only: item control page

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