Meyre, David 
, Winkler, Thomas W., Justice, Anne E., Cupples, L. Adrienne , Kronenberg, Florian, Kutalik, Zoltán and Heid, Iris M.
(2017)
Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation.
PLoS ONE 12 (7), e0181038.
| License: Creative Commons Attribution 4.0 PDF - Published Version Download (4MB) |
Other URL: http://doi.org/10.1371/journal.pone.0181038, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181038
Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.
Abstract
Genome-wide association meta-analyses (GWAMAs) conducted separately by two strata have identified differences in genetic effects between strata, such as sex-differences for body fat distribution. However, there are several approaches to identify such differences and an uncertainty which approach to use. Assuming the availability of stratified GWAMA results, we compare various approaches to ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 27 July 2017 | ||||
| Institutions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie | ||||
| Projects: | Open Access Publizieren (DFG) | ||||
| Identification Number: |
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| Keywords: | BODY-MASS INDEX; ENVIRONMENT INTERACTION; QUANTITATIVE TRAITS; FAT DISTRIBUTION; ASSOCIATION; LOCI; SUSCEPTIBILITY; EPIDEMIOLOGY; EFFICIENT; VARIANTS; | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 36536 |
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