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The presence of PD-1 positive tumor infiltrating lymphocytes in triple negative breast cancers is associated with a favorable outcome of disease

URN to cite this document:
urn:nbn:de:bvb:355-epub-366181
DOI to cite this document:
10.5283/epub.36618
Brockhoff, Gero ; Seitz, Stephan ; Weber, Florian ; Zeman, Florian ; Klinkhammer-Schalke, Monika ; Ortmann, Olaf ; Wege, Anja Kathrin
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Date of publication of this fulltext: 26 Jan 2018 14:33



Abstract

Triple negative breast cancer patients have a poor course of disease not least because of limited treatment options however immunotherapy by targeting the PD-1/PD-L1 checkpoint system is a promising strategy to improve the outcome. Here we systematically investigated the expression of PD-1 on tumor infiltrating lymphocytes and PD-L1 on both tumor and infiltrated immune cells. Moreover, the PD-L1 ...

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