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Advanced patient age at diagnosis of diffuse large B-cell lymphoma is associated with molecular characteristics including ABC-subtype and high expression of MYC

Paul, U., Richter, J., Stuhlmann-Laiesz, C., Kreuz, M., Nagel, I., Horn, H., Staiger, A. M., Aukema, S. M., Hummel, M., Ott, G., Spang, Rainer, Rosenwald, A., Feller, A. C., Cogliatti, S., Stein, H., Hansmann, M. L., Moller, P., Szczepanowski, M., Burkhardt, B., Pfreundschuh, M., Schmitz, N., Loeffler, M., Trumper, L., Siebert, R. and Klapper, W. (2017) Advanced patient age at diagnosis of diffuse large B-cell lymphoma is associated with molecular characteristics including ABC-subtype and high expression of MYC. Leuk. Lymphoma, pp. 1-9.

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Other URL: http://www.tandfonline.com/doi/abs/10.1080/10428194.2017.1365851?journalCode=ilal20


Abstract

The incidence of diffuse large B-cell lymphoma (DLBCL) increases with age being patient age at diagnosis an adverse prognostic factor. However, elderly patients are often underrepresented in common studies. To investigate the effect between age and biological characteristics in DLBCL, we analyzed data of 1534 patients encompassing all adult age groups, enriched for the age ≥75 years. Follicular ...

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Item type:Article
Date:25 August 2017
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
28838257PubMed ID
10.1080/10428194.2017.1365851DOI
Keywords:Adult patients, diffuse large B-cell lymphoma, molecular features
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:36691
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