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Advanced patient age at diagnosis of diffuse large B-cell lymphoma is associated with molecular characteristics including ABC-subtype and high expression of MYC

Paul, U. ; Richter, J. ; Stuhlmann-Laiesz, C. ; Kreuz, M. ; Nagel, I. ; Horn, H. ; Staiger, A. M. ; Aukema, S. M. ; Hummel, M. ; Ott, G. ; Spang, Rainer ; Rosenwald, A. ; Feller, A. C. ; Cogliatti, S. ; Stein, H. ; Hansmann, M. L. ; Moller, P. ; Szczepanowski, M. ; Burkhardt, B. ; Pfreundschuh, M. ; Schmitz, N. ; Loeffler, M. ; Trumper, L. ; Siebert, R. ; Klapper, W.



Abstract

The incidence of diffuse large B-cell lymphoma (DLBCL) increases with age being patient age at diagnosis an adverse prognostic factor. However, elderly patients are often underrepresented in common studies. To investigate the effect between age and biological characteristics in DLBCL, we analyzed data of 1534 patients encompassing all adult age groups, enriched for the age 75 years. Follicular ...

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