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Srebp-controlled glucose metabolism is essential for NK cell functional responses

Assmann, N. ; O'Brien, K. L. ; Donnelly, R. P. ; Dyck, L. ; Zaiatz-Bittencourt, V. ; Loftus, R. M. ; Heinrich, Paul ; Oefner, Peter J. ; Lynch, L. ; Gardiner, C. M. ; Dettmer, Katja ; Finlay, D. K.



Abstract

Activated natural killer (NK) cells engage in a robust metabolic response that is required for normal effector function. Using genetic, pharmacological and metabolic analyses, we demonstrated an essential role for Srebp transcription factors in cytokineinduced metabolic reprogramming of NK cells that was independent of their conventional role in the control of lipid synthesis. Srebp was required ...

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