Go to content
UR Home

Srebp-controlled glucose metabolism is essential for NK cell functional responses

Assmann, N., O'Brien, K. L., Donnelly, R. P., Dyck, L., Zaiatz-Bittencourt, V., Loftus, R. M., Heinrich, Paul, Oefner, Peter J., Lynch, L., Gardiner, C. M., Dettmer, Katja and Finlay, D. K. (2017) Srebp-controlled glucose metabolism is essential for NK cell functional responses. Nat. Immunol. 18 (11), pp. 1197-1206.

Full text not available from this repository.

at PubMed

at publisher (via DOI)

Other URL: https://www.nature.com/articles/ni.3838


Abstract

Activated natural killer (NK) cells engage in a robust metabolic response that is required for normal effector function. Using genetic, pharmacological and metabolic analyses, we demonstrated an essential role for Srebp transcription factors in cytokineinduced metabolic reprogramming of NK cells that was independent of their conventional role in the control of lipid synthesis. Srebp was required ...

plus


Export bibliographical data



Item type:Article
Date:November 2017
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
28920951PubMed ID
10.1038/ni.3838DOI
Keywords:NATURAL-KILLER-CELLS; ELEMENT-BINDING PROTEINS; FATTY-ACID SYNTHESIS; T-CELLS; EFFECTOR FUNCTION; LIPID-SYNTHESIS; METHYL-ESTERS; ACTIVATION; MEMORY; GENE;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:36692
Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons