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From Discovery to Translation: Characterization of C-Mannosyltryptophan and Pseudouridine as Markers of Kidney Function

Sekula, P. ; Dettmer, Katja ; Vogl, Franziska C. ; Gronwald, Wolfram ; Ellmann, Lisa ; Mohney, R. P. ; Eckardt, K. U. ; Suhre, K. ; Kastenmüller, Gabi ; Oefner, Peter J. ; Köttgen, A.


Using a non-targeted metabolomics platform, we recently identified C-mannosyltryptophan and pseudouridine as non-traditional kidney function markers. The aims of this study were to obtain absolute concentrations of both metabolites in blood and urine from individuals with and without CKD to provide reference ranges and to assess their fractional excretions (FE), and to assess the agreement with ...


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