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Fabrication of antibody-​loaded microgels using microfluidics and thiol-​ene photoclick chemistry

Gregoritza, Manuel , Abstiens, Kathrin, Graf, Moritz and Göpferich, Achim (2018) Fabrication of antibody-​loaded microgels using microfluidics and thiol-​ene photoclick chemistry. European Journal of Pharmaceutics and Biopharmaceutics 127, pp. 194-203.

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Abstract

Reducing burst effects, providing controlled release, and safeguarding biologics against degradation are a few of several highly attractive applications for microgels in the field of controlled release. However, the incorporation of proteins into microgels without impairing stability is highly challenging. In this proof of concept study, the combination of microfluidics and thiol-ene photoclick ...

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Item type:Article
Date:2018
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1016/j.ejpb.2018.02.024DOI
Keywords:Microgel Click chemistry Thiol-ene reaction Protein delivery Microfluidics Controlled release
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36857
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