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Do Neuroendocrine Peptides and Their Receptors Qualify as Novel Therapeutic Targets in Osteoarthritis?

URN to cite this document:
urn:nbn:de:bvb:355-epub-368583
DOI to cite this document:
10.5283/epub.36858
Grässel, Susanne ; Muschter, Dominique
Date of publication of this fulltext: 05 Mar 2018 16:58



Abstract

Joint tissues like synovium, articular cartilage, meniscus and subchondral bone, are targets for neuropeptides. Resident cells of these tissues express receptors for various neuroendocrine-derived peptides including proopiomelanocortin (POMC)-derived peptides, i.e., α-melanocyte-stimulating hormone (α-MSH), adrenocorticotropin (ACTH) and β-endorphin (β-ED), and sympathetic neuropeptides like ...

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