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The role of the inwardly rectifying potassium channel Kir5.1 in the distal convoluted tubule

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Quintanova, Catarina Isabel Rina
Date of publication of this fulltext: 19 Mar 2018 09:57

Abstract (English)

In the kidney, inwardly rectifying K+ channels of the Kir (KCNJ) family are essential for the control of salt transport. In the basolateral membrane of distal convoluted tubules (DCT), Kir4.1 (KCNJ10) together with Kir5.1 (KCNJ16) appears to be relevant for salt transport and adaptation of DCT to plasma K+ levels, so called K+ sensing. Loss-of-function mutations in KCNJ10 are known to result in ...


Translation of the abstract (German)

In der Niere spielen die einwärtsgleichrichtenden K+-Kanäle Kir4.1 (KCNJ10) und Kir5.1 (KCNJ16) eine wichtige Rolle. In der basolateralen Membran des distalen Konvoluts (DCT) sind Kir4.1/Kir5.1-Kanäle entscheidend für den Salztransport und die Anpassung des Transports an das Plasma-K+, das so genannte “K+ Sensing”. Mutationen von KCNJ10 führen zum EAST/SeSAME-Syndrom, einem komplexen ...


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