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The role of the inwardly rectifying potassium channel Kir5.1 in the distal convoluted tubule

Quintanova, Catarina Isabel Rina (2018) The role of the inwardly rectifying potassium channel Kir5.1 in the distal convoluted tubule. PhD, Universität Regensburg.

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Date of publication of this fulltext: 19 Mar 2018 09:57

Abstract (English)

In the kidney, inwardly rectifying K+ channels of the Kir (KCNJ) family are essential for the control of salt transport. In the basolateral membrane of distal convoluted tubules (DCT), Kir4.1 (KCNJ10) together with Kir5.1 (KCNJ16) appears to be relevant for salt transport and adaptation of DCT to plasma K+ levels, so called K+ sensing. Loss-of-function mutations in KCNJ10 are known to result in ...

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Translation of the abstract (German)

In der Niere spielen die einwärtsgleichrichtenden K+-Kanäle Kir4.1 (KCNJ10) und Kir5.1 (KCNJ16) eine wichtige Rolle. In der basolateralen Membran des distalen Konvoluts (DCT) sind Kir4.1/Kir5.1-Kanäle entscheidend für den Salztransport und die Anpassung des Transports an das Plasma-K+, das so genannte “K+ Sensing”. Mutationen von KCNJ10 führen zum EAST/SeSAME-Syndrom, einem komplexen ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:19 March 2018
Referee:Prof. Dr. med Richard Warth and Prof. Dr. rer Charlotte Wagner and Prof. Dr. rer Gernot Längst
Date of exam:15 March 2018
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Richard Warth
Keywords:inwardly rectifying potassium channel distal convoluted tubule hypokalemia
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36899
Owner only: item control page

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