Go to content
UR Home

Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma

Werner-Klein, Melanie , Scheitler, Sebastian, Hoffmann, Martin , Hodak, Isabelle , Dietz, Klaus, Lehnert, Petra, Naimer, Veronika, Polzer, Bernhard , Treitschke, Steffi, Werno, Christian, Markiewicz, Aleksandra, Weidele, Kathrin, Czyz, Zbigniew, Hohenleutner, Ulrich, Hafner, Christian, Haferkamp, Sebastian, Berneburg, Mark, Rümmele, Petra , Ulmer, Anja and Klein, Christoph A. (2018) Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma. Nature Communications 9 (595), pp. 1-17.

[img]
Preview
License: Creative Commons Attribution 4.0
PDF
Download (4MB)
Date of publication of this fulltext: 27 Mar 2018 12:14

at publisher (via DOI)

Other URL: http://doi.org/10.1038/s41467-017-02674-y


Abstract

Mouse models indicate that metastatic dissemination occurs extremely early; however, the timing in human cancers is unknown. We therefore determined the time point of metastatic seeding relative to tumour thickness and genomic alterations in melanoma. Here, we find that lymphatic dissemination occurs shortly after dermal invasion of the primary lesion at a median thickness of ~0.5 mm and that ...

plus


Export bibliographical data



Item type:Article
Date:9 February 2018
Institutions:Medicine > Lehrstuhl für experimentelle Medizin und Therapieverfahren
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1038/s41467-017-02674-yDOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36938
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons