Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma

• URN zum Zitieren dieses Dokuments: urn:nbn:de:bvb:355-epub-369383

Werner-Klein, Melanie , Scheitler, Sebastian, Hoffmann, Martin , Hodak, Isabelle , Dietz, Klaus, Lehnert, Petra, Naimer, Veronika, Polzer, Bernhard , Treitschke, Steffi, Werno, Christian, Markiewicz, Aleksandra, Weidele, Kathrin, Czyz, Zbigniew, Hohenleutner, Ulrich, Hafner, Christian, Haferkamp, Sebastian, Berneburg, Mark, Rümmele, Petra , Ulmer, Anja und Klein, Christoph A. (2018) Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma. Nature Communications 9 (595), S. 1-17.

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Andere URL zum Volltext: http://doi.org/10.1038/s41467-017-02674-y

Zusammenfassung

Mouse models indicate that metastatic dissemination occurs extremely early; however, the timing in human cancers is unknown. We therefore determined the time point of metastatic seeding relative to tumour thickness and genomic alterations in melanoma. Here, we find that lymphatic dissemination occurs shortly after dermal invasion of the primary lesion at a median thickness of ~0.5 mm and that ...

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