Werner-Klein, Melanie 
, Scheitler, Sebastian, Hoffmann, Martin , Hodak, Isabelle , Dietz, Klaus, Lehnert, Petra, Naimer, Veronika, Polzer, Bernhard , Treitschke, Steffi, Werno, Christian, Markiewicz, Aleksandra, Weidele, Kathrin, Czyz, Zbigniew, Hohenleutner, Ulrich, Hafner, Christian, Haferkamp, Sebastian, Berneburg, Mark, Rümmele, Petra , Ulmer, Anja and Klein, Christoph A.
(2018)
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma.
Nature Communications 9 (595), pp. 1-17.
| License: Creative Commons Attribution 4.0 Download (4MB) |
Other URL: http://doi.org/10.1038/s41467-017-02674-y
Abstract
Mouse models indicate that metastatic dissemination occurs extremely early; however, the timing in human cancers is unknown. We therefore determined the time point of metastatic seeding relative to tumour thickness and genomic alterations in melanoma. Here, we find that lymphatic dissemination occurs shortly after dermal invasion of the primary lesion at a median thickness of ~0.5 mm and that ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 9 February 2018 | ||||
| Institutions: | Medicine > Lehrstuhl für experimentelle Medizin und Therapieverfahren | ||||
| Projects: | Open Access Publizieren (DFG) | ||||
| Identification Number: |
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| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 36938 |
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