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Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma

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Werner-Klein, Melanie ; Scheitler, Sebastian ; Hoffmann, Martin ; Hodak, Isabelle ; Dietz, Klaus ; Lehnert, Petra ; Naimer, Veronika ; Polzer, Bernhard ; Treitschke, Steffi ; Werno, Christian ; Markiewicz, Aleksandra ; Weidele, Kathrin ; Czyz, Zbigniew ; Hohenleutner, Ulrich ; Hafner, Christian ; Haferkamp, Sebastian ; Berneburg, Mark ; Rümmele, Petra ; Ulmer, Anja ; Klein, Christoph A.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 27 Mar 2018 12:14


Mouse models indicate that metastatic dissemination occurs extremely early; however, the timing in human cancers is unknown. We therefore determined the time point of metastatic seeding relative to tumour thickness and genomic alterations in melanoma. Here, we find that lymphatic dissemination occurs shortly after dermal invasion of the primary lesion at a median thickness of similar to 0.5mm and ...


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