Systematic Evaluation of Non-Uniform Sampling Parameters in the Targeted Analysis of Urine Metabolites by1H,1H 2D NMR Spectroscopy

URN to cite this document:: urn:nbn:de:bvb:355-epub-369477
DOI to cite this document:: 10.5283/epub.36947

von Schlippenbach, Trixi

; Oefner, Peter J. ; Gronwald, Wolfram

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Date of publication of this fulltext: 28 Mar 2018 07:23

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Abstract

Non-uniform sampling (NUS) allows the accelerated acquisition of multidimensional NMR spectra. The aim of this contribution was the systematic evaluation of the impact of various quantitative NUS parameters on the accuracy and precision of 2D NMR measurements of urinary metabolites. Urine aliquots spiked with varying concentrations (15.6-500.0 mu M) of tryptophan, tyrosine, glutamine, glutamic ...