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Polyol pathway links glucose metabolism to the aggressiveness of cancer cells

Schwab, A., Siddiqui, A., Vazakidou, M. E., Napoli, F., Bottcher, M., Menchicchi, B., Raza, U., Saatci, O., Krebs, A. M., Ferrazzi, F., Rapa, I., Dettmer-Wilde, Katja, Waldner, M. J., Ekici, A. B., Rasheed, S. A. K., Mougiakakos, D., Oefner, Peter J., ?ahin, O., Volante, M., Greten, F. R., Brabletz, T. and Ceppi, P. (2018) Polyol pathway links glucose metabolism to the aggressiveness of cancer cells. Cancer Res..

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Abstract

Cancer cells alter their metabolism to support their malignant properties. In this study, we report that the glucose-transforming polyol pathway (PP) gene aldo-keto-reductase-1-member-B1 (AKR1B1) strongly correlates with epithelial-to-mesenchymal transition (EMT). This association was confirmed in samples from lung cancer patients and from an EMT-driven colon cancer mouse model with p53 deletion. ...

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Item type:Article
Date:17 January 2018
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
29343522PubMed ID
10.1158/0008-5472.CAN-17-2834DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:36949
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