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Polyol pathway links glucose metabolism to the aggressiveness of cancer cells

Schwab, A. ; Siddiqui, A. ; Vazakidou, M. E. ; Napoli, F. ; Boettcher, M. ; Menchicchi, B. ; Raza, U. ; Saatci, Ö. ; Krebs, A. M. ; Ferrazzi, F. ; Rapa, I. ; Dettmer-Wilde, Katja ; Waldner, M. J. ; Ekici, A. B. ; Rasheed, S. A. K. ; Mougiakakos, D. ; Oefner, Peter J. ; Sahin, O. ; Volante, M. ; Greten, F. R. ; Brabletz, T. ; Ceppi, P.


Cancer cells alter their metabolism to support their malignant properties. In this study, we report that the glucose-transforming polyol pathway (PP) gene aldo-keto-reductase-1-member-B1 (AKR1B1) strongly correlates with epithelial-to-mesenchymal transition (EMT). This association was confirmed in samples from lung cancer patients and from an EMT-driven colon cancer mouse model with p53 deletion. ...


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