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Unbound fraction of fluconazole and linezolid in human plasma as determined by ultrafiltration: Impact of membrane type

Kratzer, Alexander, Kees, Frieder and Dorn, Christoph (2016) Unbound fraction of fluconazole and linezolid in human plasma as determined by ultrafiltration: Impact of membrane type. Journal of Chromatography B 1039, pp. 74-78.

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Other URL: http://doi.org/10.1016/j.jchromb.2016.10.040


Abstract

Ultrafiltration is a rapid and convenient method to determine the free concentrations of drugs in plasma. Several ultrafiltration devices based on Eppendorf cups are commercially available, but are not validated for such use by the manufacturer. Plasma pH, temperature and relative centrifugal force as well as membrane type can influence the results. In the present work, we developed an ...

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Item type:Article
Date:2016
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Group Clinical Pharmacy (Dr. Dorn)
Identification Number:
ValueType
10.1016/j.jchromb.2016.10.040DOI
Keywords:HPLC, Antiinfectives, Protein binding, Patients, Polyethersulfone, Regenerated cellulose
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36968
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