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Decreased protein binding of moxifloxacin in patients with sepsis?

Dorn, Christoph , Nowak, Hartmuth, Weidemann, Caroline, Martini, Stefan, Zeitlinger, Markus, Adamzik, Michael and Kees, Frieder K. (2017) Decreased protein binding of moxifloxacin in patients with sepsis? GMS Infectious Diseases 2017 (5), Doc03.

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The mean (SD) unbound fraction of moxifloxacin in plasma from patients with severe sepsis or septic shock was determined by ultrafiltration to 85.5±3.0% (range 81.9 and 91.6%) indicating a decreased protein binding of moxifloxacin in this population compared with the value of 58–60% provided in the Summary of Product Characteristics. However, previous investigations neglected the influence of pH ...


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Item type:Article
Date:3 February 2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Group Clinical Pharmacy (Dr. Dorn)
Identification Number:
Keywords:fluoroquinolone, unbound fraction, ultrafiltration, septic shock
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36969
Owner only: item control page


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