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Decreased protein binding of moxifloxacin in patients with sepsis?

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Dorn, Christoph ; Nowak, Hartmuth ; Weidemann, Caroline ; Martini, Stefan ; Zeitlinger, Markus ; Adamzik, Michael ; Kees, Frieder K.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 06 Apr 2018 06:40


The mean (SD) unbound fraction of moxifloxacin in plasma from patients with severe sepsis or septic shock was determined by ultrafiltration to 85.5±3.0% (range 81.9 and 91.6%) indicating a decreased protein binding of moxifloxacin in this population compared with the value of 58–60% provided in the Summary of Product Characteristics. However, previous investigations neglected the influence of pH ...


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