CYLD controls c-MYC expression through the JNK-dependent signaling pathway in hepatocellular carcinoma

URN to cite this document:: urn:nbn:de:bvb:355-epub-534222
DOI to cite this document:: 10.5283/epub.36973

Pannem, Rajeswara Rao ; Dorn, Christoph

; Ahlqvist, Kristofer ; Bosserhoff, Anja K. ; Hellerbrand, Claus ; Massoumi, Ramin

Preview

PDF
(3MB)

Date of publication of this fulltext: 06 Apr 2018 06:41

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

Posttranslational modification of different proteins via direct ubiquitin attachment is vital for mediating various cellular processes. Cylindromatosis (CYLD), a deubiquitination enzyme, is able to cleave the polyubiquitin chains from the substrate and to regulate different signaling pathways. Loss, or reduced expression, of CYLD is observed in different types of human cancer, such as ...