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CYLD controls c-MYC expression through the JNK-dependent signaling pathway in hepatocellular carcinoma

URN to cite this document:
urn:nbn:de:bvb:355-epub-534222
Pannem, Rajeswara Rao ; Dorn, Christoph ; Ahlqvist, Kristofer ; Bosserhoff, Anja K. ; Hellerbrand, Claus ; Massoumi, Ramin
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Date of publication of this fulltext: 06 Apr 2018 06:41


Abstract

Posttranslational modification of different proteins via direct ubiquitin attachment is vital for mediating various cellular processes. Cylindromatosis (CYLD), a deubiquitination enzyme, is able to cleave the polyubiquitin chains from the substrate and to regulate different signaling pathways. Loss, or reduced expression, of CYLD is observed in different types of human cancer, such as ...

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