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Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis

URN to cite this document:
urn:nbn:de:bvb:355-epub-370371
DOI to cite this document:
10.5283/epub.37037
Dorn, Christoph ; Heilmann, Jörg ; Hellerbrand, Claus
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Date of publication of this fulltext: 11 Apr 2018 10:17


Abstract

Xanthohumol, the major prenylated chalcone found in hops, is known for its anti-inflammatory properties. We have recently shown that xanthohumol inhibits hepatic inflammation and fibrosis in a murine model of nonalcoholic steatohepatitis. The aim of this study was to investigate the effect of xanthohumol in an acute model of liver injury. Carbon tetrachloride (CCl(4)), an industrial solvent, is a ...

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