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Sterol Regulatory Element-Binding Protein 2 (SREBP2) Activation after Excess Triglyceride Storage Induces Chemerin in Hypertrophic Adipocytes

Bauer, Sabrina ; Wanninger, Josef ; Schmidhofer, Sandra ; Weigert, Johanna ; Neumeier, Markus ; Dorn, Christoph ; Hellerbrand, Claus ; Zimara, Nicole ; Schäffler, Andreas ; Aslanidis, Charalampos ; Buechler, Christa

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Chemerin is an adipokine whose systemic concentration and adipose tissue expression is increased in obesity. Chemerin is highly abundant in adipocytes, yet the molecular mechanisms mediating its further induction in obesity have not been clarified. Adipocyte hypertrophy contributes to dysregulated adipokine synthesis, and we hypothesized that excess loading with free fatty acids (FFA) stimulates ...


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