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Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis

Patsenker, Eleonora ; Schneider, Vreni ; Ledermann, Monika ; Saegesser, Hans ; Dorn, Christoph ; Hellerbrand, Claus ; Stickel, Felix

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Abstract

Background & Aims Recurrence of chronic hepatitis C and progressive fibrosis in liver transplants is frequent and impairs both graft and patient survival. Whether or not the choice of immunosuppression affects progression of fibrosis remains unclear. The aim of the present study was to compare the potential of the commonly used immunosuppressants to halt experimental liver fibrosis ...

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