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A New Model of Interactive Effects of Alcohol and High-Fat Diet on Hepatic Fibrosis

Gäbele, Erwin ; Dostert, Karin ; Dorn, Christoph ; Patsenker, Eleonora ; Stickel, Felix ; Hellerbrand, Claus

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Abstract

Background:  Alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH) are the most frequent conditions leading to elevated liver enzymes and liver cirrhosis, respectively, in the Western world. However, despite strong epidemiological evidence for combined effects on the progression of liver injury, the mutual interaction of the pathophysiological mechanisms is incompletely ...

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