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Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes

Wanninger, Josef ; Neumeier, Markus ; Bauer, Sabrina ; Weiss, Thomas S. ; Eisinger, Kristina ; Walter, Roland ; Dorn, Christoph ; Hellerbrand, Claus ; Schäffler, Andreas ; Buechler, Christa

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Abstract

Transforming growth factor (TGF) β is the central cytokine in fibrotic liver diseases. We analyzed whether hepatoprotective adiponectin directly interferes with TGFβ1 signaling in primary human hepatocytes (PHH). Adiponectin induces the TGFβ decoy receptor BMP‐and activin‐membrane‐bound inhibitor (BAMBI) in PHH. Overexpression of BAMBI in hepatoma cells impairs TGFβ‐mediated phosphorylation of ...

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