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Expression of fatty acid synthase in nonalcoholic fatty liver disease

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Dorn, Christoph ; Riener, Marc-Oliver ; Kirovski, Georgi ; Saugspier, Michael ; Steib, Kathrin ; Weiss, Thomas S. ; Gäbele, Erwin ; Kristiansen, Glen ; Hartmann, Arndt ; Hellerbrand, Claus
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Date of publication of this fulltext: 10 Apr 2018 12:09


Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation which starts with simple hepatic steatosis and may progress toward inflammation (nonalcoholic steatohepatitis [NASH]). Fatty acid synthase (FASN) catalyzes the last step in fatty acid biosynthesis, and thus, it is believed to be a major determinant of the maximal hepatic capacity to generate fatty acids by de ...


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