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Hepatic steatosis causes induction of the chemokine RANTES in the absence of significant hepatic inflammation

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Kirovski, Georgi ; Gäbele, Erwin ; Dorn, Christoph ; Moleda, Lukas ; Niessen, Christoph ; Weiss, Thomas S. ; Wobser, Hella ; Schacherer, Doris ; Buechler, Christa ; Wasmuth, Hermann E. ; Hellerbrand, Claus
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Date of publication of this fulltext: 10 Apr 2018 11:50


Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum ranging from simple steatosis to cirrhosis. Hepatocellular lipid accumulation is a hallmark of both nonalcoholic steatosis and steatohepatitis (NASH). The latter develops upon pro-inflammatory cell infiltration and is widely considered as the first relevant pathophysiological step in NAFLD-progression. The chemokine CCL5/RANTES plays ...


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