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Extracellular citrate affects critical elements of cancer cell metabolism and supports cancer development in vivo

Mycielska, M. E. ; Dettmer-Wilde, Katja ; Rümmele, P. ; Schmidt, K. M. ; Prehn, C. ; Milenkovic, V. ; Jagla, W. ; Madej, M. G. ; Lantow, M. ; Schladt, M. T. ; Cecil, A. ; Koehl, G. E. ; Eggenhofer, E. ; Wachsmuth, C. ; Ganapathy, V. ; Schlitt, H. J. ; Kunzelmann, K. ; Ziegler, C. ; Wetzel, C. H. ; Gaumann, A. ; Lang, S. A. ; Adamski, J. ; Oefner, Peter J. ; Geissler, E. K.



Abstract

Glycolysis and fatty acid synthesis are highly active in cancer cells through cytosolic citrate metabolism, with intracellular citrate primarily derived from either glucose or glutamine via the tricarboxylic acid cycle. We show here that extracellular citrate is supplied to cancer cells through a plasma membrane-specific variant of the mitochondrial citrate transporter (pmCiC). Metabolomic ...

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