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Extracellular citrate affects critical elements of cancer cell metabolism and supports cancer development in vivo

Mycielska, M. E., Dettmer-Wilde, Katja, Rummele, P., Schmidt, K. M., Prehn, C., Milenkovic, V., Jagla, W., Madej, M. G., Lantow, M., Schladt, M. T., Cecil, A., Koehl, G. E., Eggenhofer, E., Wachsmuth, C., Ganapathy, V., Schlitt, H. J., Kunzelmann, K., Ziegler, C., Wetzel, C. H., Gaumann, A., Lang, S. A., Adamski, J., Oefner, Peter J. and Geissler, E. K. (2018) Extracellular citrate affects critical elements of cancer cell metabolism and supports cancer development in vivo. Cancer research.

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Other URL: http://cancerres.aacrjournals.org/content/early/2018/03/06/0008-5472.CAN-17-2959.article-info


Abstract

Glycolysis and fatty acid synthesis are highly active in cancer cells through cytosolic citrate metabolism, with intracellular citrate primarily derived from either glucose or glutamine via the tricarboxylic acid cycle. We show here that extracellular citrate is supplied to cancer cells through a plasma membrane-specific variant of the mitochondrial citrate transporter (pmCiC). Metabolomic ...

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Item type:Article
Date:6 March 2018
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
29510993PubMed ID
10.1158/0008-5472.CAN-17-2959DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:37212
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