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Photochromic Indolyl Fulgimides as Chromo-Pharmacophores Targeting Sirtuins

Simeth, Nadja Anita ; Altmann, Lisa-Marie ; Woessner, Nathalie ; Bauer, Elisabeth ; Jung, Manfred ; König, Burkhard



Abstract

Sirtuins are involved in epigenetic regulation, the pathogenesis of cancer, and several metabolic and neurodegenerative diseases. Despite being a promising drug target, only one small molecule passed class II clinical trials to date. Deriving a better mechanistic understanding is hence crucial to find new modulators. We previously reported on a series of dithienyl maleimides as photochromic tool ...

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