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Photochromic Indolyl Fulgimides as Chromo-Pharmacophores Targeting Sirtuins

Simeth, Nadja Anita, Altmann, Lisa-Marie, Woessner, Nathalie, Bauer, Elisabeth, Jung, Manfred and König, Burkhard (2018) Photochromic Indolyl Fulgimides as Chromo-Pharmacophores Targeting Sirtuins. The Journal of Organic Chemistry 83, pp. 7919-7927.

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Sirtuins are involved in epigenetic regulation, the pathogenesis of cancer and, several metabolic and neurodegenerative diseases. Though being a promising drug target, only one small molecule passed class II clinical trials so far. Deriving a better mechanistic understanding is hence crucial to find new modulators. We previously reported on a series of dithienyl maleimides as photochromic tool ...


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Item type:Article
Date:1 June 2018
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
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Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:37394
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