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Transfection of Antisense Oligonucleotides Mediated by Cationic Vesicles Based on Non-Ionic Surfactant and Polycations Bearing Quaternary Ammonium Moieties

Mayr, Judith, Grijalvo, Santiago , Bachl, Jürgen, Eritja, Ramon , Díaz Díaz, David and make_name_string expected hash reference (2017) Transfection of Antisense Oligonucleotides Mediated by Cationic Vesicles Based on Non-Ionic Surfactant and Polycations Bearing Quaternary Ammonium Moieties. International Journal of Molecular Sciences 18, p. 1169.

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Date of publication of this fulltext: 04 Jul 2018 12:22

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Abstract

Three different ionene polymers with varying quaternary ammonium moieties were used as a proof of concept for the formulation of antisense oligonucleotides, which are capable of inhibiting Renilla luciferase messenger ribonucleic acid (mRNA). Cationic vesicles, consisting of cationic polymer, antisense oligonucleotide (Luc) and non-ionic surfactant polysorbate 80, were investigated regarding ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. David Díaz Díaz
Identification Number:
ValueType
10.3390/ijms18061139DOI
Keywords:GENE DELIVERY; DNA; POLYMERS; TOXICITY; AMPHIPHILE; EFFICIENCY; HYDRATION; IONENES; COMPLEX; AGENTS; antisense oligonucleotide; cationic polymers; cationic vesicles; ionenes; transfection; polycations; polyplexes; quaternary ammonium
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37456
Owner only: item control page

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