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Transfection of Antisense Oligonucleotides Mediated by Cationic Vesicles Based on Non-Ionic Surfactant and Polycations Bearing Quaternary Ammonium Moieties

URN to cite this document:
urn:nbn:de:bvb:355-epub-374567
Mayr, Judith ; Grijalvo, Santiago ; Bachl, Jürgen ; Eritja, Ramon ; Díaz Díaz, David ;
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Date of publication of this fulltext: 04 Jul 2018 12:22


Abstract

Three different ionene polymers with varying quaternary ammonium moieties were used as a proof of concept for the formulation of antisense oligonucleotides, which are capable of inhibiting Renilla luciferase messenger ribonucleic acid (mRNA). Cationic vesicles, consisting of cationic polymer, antisense oligonucleotide (Luc) and non-ionic surfactant polysorbate 80, were investigated regarding ...

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