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Proteome Analysis of Human Follicular Thyroid Cancer Cells Exposed to the Random Positioning Machine

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Bauer, Johann ; Kopp, Sascha ; Schlagberger, Elisabeth Maria ; Grosse, Jirka
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 05 Jul 2018 12:16


Several years ago, we detected the formation of multicellular spheroids in experiments with human thyroid cancer cells cultured on the Random Positioning Machine (RPM), a ground-based model to simulate microgravity by continuously changing the orientation of samples. Since then, we have studied cellular mechanisms triggering the cells to leave a monolayer and aggregate to spheroids. Our work ...


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