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Transfusion-transmitted hepatitis E in Germany, 2013

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Huzly, D. ; Umhau, M. ; Bettinger, D. ; Cathomen, T. ; Emmerich, F. ; Hasselblatt, P. ; Hengel, H. ; Herzog, R. ; Kappert, O. ; Maassen, S. ; Schorb, E. ; Schulz-Huotari, C. ; Thimme, R. ; Unmussig, R. ; Wenzel, Jürgen J. ; Panning, M.
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Date of publication of this fulltext: 19 Jul 2018 08:54


The reported IgG seroprevalence against hepatitis E virus (HEV) in German blood donations is 6.8%, and HEV RNA detected in 0.08%, but documented evidence for HEV transmission is lacking. We identified two donations from a single donor containing 120 IU HEV RNA/mL plasma and 490 IU/mL. An infectious dose of 7,056 IU HEV RNA was transmitted via apheresis platelets to an immunosuppressed patient who developed chronic HEV. Further, transmission was probable in an immunocompetent child.

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