Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

URN to cite this document:: urn:nbn:de:bvb:355-epub-375408
DOI to cite this document:: 10.5283/epub.37540

Loftus, R. M.

; Assmann, N. ; Kedia-Mehta, N. ; O'Brien, K. L. ; Garcia, A. ; Gillespie, C. ; Hukelmann, J. L.

; Oefner, Peter J. ; Lamond, A. I. ; Gardiner, C. M.

; Dettmer, Katja ; Cantrell, D. A. ; Sinclair, L. V. ; Finlay, D. K.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 19 Jul 2018 08:42

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Abstract

Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine activation of NK cell glycolysis and oxidative phosphorylation (OXPHOS) are essential for robust NK cell responses. However, the mechanisms leading to this metabolic phenotype are unclear. Here we show that the transcription factor cMyc is essential for IL-2/IL-12-induced metabolic and functional responses in ...