Go to content
UR Home

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, Peter J. , Lamond, A. I., Gardiner, C. M., Dettmer, Katja , Cantrell, D. A., Sinclair, L. V. and Finlay, D. K. (2018) Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice. Nat Commun 9 (1), p. 2341.

[img]License: Creative Commons Attribution 4.0
PDF - Published Version
Download (2MB)
Date of publication of this fulltext: 19 Jul 2018 08:42

at PubMed

at publisher (via DOI)

Other URL: https://www.nature.com/articles/s41467-018-04719-2


Abstract

Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine activation of NK cell glycolysis and oxidative phosphorylation (OXPHOS) are essential for robust NK cell responses. However, the mechanisms leading to this metabolic phenotype are unclear. Here we show that the transcription factor cMyc is essential for IL-2/IL-12-induced metabolic and functional responses in ...

plus


Export bibliographical data



Item type:Article
Date:14 June 2018
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
29904050PubMed ID
10.1038/s41467-018-04719-2DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:37540
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons