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Urea Activation by an External Brønsted Acid: Breaking Self-Association and Tuning Catalytic Performance

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Sonsona, Isaac G. ; Marqués-López, Eugenia ; Häring, Marleen ; Díaz Díaz, David ; Herrera, Raquel P.
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Date of publication of this fulltext: 29 Aug 2018 13:21


In this work, we hypothesize that Bronsted acids can activate urea-based catalysts by diminishing its self-assembly tendency. As a proof of concept, we used the asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes as a benchmark reaction. The resulting 3-substituted indole derivatives were obtained with better results due to cooperative effects of the chiral urea and a Bronsted acid ...


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