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Safety, Tolerability and Clinical Effects of a Rapid Dose Titration of Subcutaneous Treprostinil Therapy in Pulmonary Arterial Hypertension: A Prospective Multi-Centre Trial

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Grüning, Ekkehard ; Benjamin, Nicola ; Lange, Tobias J. ; Krueger, Ulrich ; Klose, Hans ; Neuroher, Claus ; Wilkens, Heinrike ; Halank, Michael ; Seyfarth, Hans-Jürgen ; Held, Matthias ; Traube, Andrew ; Pernow, Michelle ; Grover, E. Robert ; Egenlauf, Benjamin ; Gerhardt, Felix ; Viethen, Thomas ; Rosenkranz, Stephan
[img]License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 28 Aug 2018 14:38


Background: Subcutaneous treprostinil has dose-dependent beneficial effects in patients with severe pulmonary arterial hypertension, but adverse effects like infusion site pain can lead to treatment discontinuation. Objectives: The objective of this study was to evaluate safety, tolerability and clinical effects of a rapid up-titration dosing regimen of subcutaneous treprostinil using proactive ...


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