Frequency of TERT Promoter Mutations in Prostate Cancer

URN to cite this document:: urn:nbn:de:bvb:355-epub-376596
DOI to cite this document:: 10.5283/epub.37659

Stoehr, Robert ; Taubert, Helge ; Zinnall, Ulrike ; Giedl, Johannes ; Gaisa, Nadine T. ; Burger, Maximilian ; Ruemmele, Petra ; Hurst, Carolyn D. ; Knowles, Margaret A. ; Wullich, Bernd ; Hartmann, Arndt

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Date of publication of this fulltext: 28 Aug 2018 14:03

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Abstract

Objective: Recently, recurrent mutations within the core promoter of the human telomerase reverse transcriptase (TERT) gene generating consensus binding sites for ETS transcription factor family members were described in melanomas and other malignancies (e.g. bladder cancer, hepatocellular carcinoma). These mutations were discussed as early drivers for malignant transformation. In prostate cancer ...