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Structural and functional analysis of MscS-like channels from Nanoarchaeum equitans

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Berlik, Pia
Date of publication of this fulltext: 01 Apr 2019 05:19

Abstract (English)

Mechanosensitive (MS) channels are found throughout all domains of life since maintaining the intracellular homeostasis is crucial for all living cells. Bacterial MS channels represent the best-characterized force-sensing system. They mainly act as “emergency relief valves” by directly sensing elevated membrane tension as a consequence of osmotic down-shock. Upon opening, the channels release ...


Translation of the abstract (German)

Mechanosensitive Känale finden sich in allen Domänen des Lebens, da die Aufrechterhaltung der intrazellulären Homeostase essentiell für alle Zellen ist. Hierbei gelten bakterielle mechanosensitive Kanäle als das bisher am besten untersuchte "force-sensing" System. Als sogenannte “Notfallventile” reagieren diese unmittelbar auf eine erhöhte Membranspannung, welche durch einen hypoosmotischen ...


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